Clean non-suede leather moccasins with a high-quality saddle soap or leather cleaner. Dip a damp sponge into the cleaner, then clean the leather, using a circular motion, to create a foam. Blot the foam with a clean, dry cloth, then use a separate clean cloth to buff the leather. Let the leather air dry overnight before wearing.

Apply leather conditioner to soften and lubricate the leather and protect the surface from dirt and stains. Moisten a sponge with the conditioner, then use circular motions to rub the conditioner into the moccasins. Buff the leather with a soft, dry cloth, then allow the moccasins to air dry. Reapply conditioner after every cleaning.

Clean sheepskin moccasin liners with a mild shampoo or liquid soap. Rinse the shampoo carefully, then allow the moccasins to dry overnight. If the liners are removable, hand-wash them and allow them to dry before putting them back in the moccasins.

Weatherproof moccasins with beeswax if you wear them outdoors, especially if you live in a damp climate. Place the beeswax in a double boiler and heat it over low heat until it softens. Rub the softened beeswax into the leather, working it in thoroughly along the seams to provide additional protection. Let the moccasins dry, then buff them with a soft cloth.

Clean suede moccasins regularly by brushing the moccasins with a suede brush. If the moccasins are heavily soiled, rub the surface lightly with fine sandpaper or use a cleaning kit made specifically for suede. Remove small stains with a suede eraser or a damp sponge.

Sprinkle the inside of moccasins lightly with baking soda if they develop a musky odor. Leave the moccasins overnight, then shake out the baking soda in the morning.