The Best Idebenone Wrinkle Creams

Idebenone is a naturally occurring compound in the quinone family that is used to treat degenerative nervous system diseases in Europe. According to the Muscular Dystrophy Association, it has antioxidant properties similar to those of co-enzyme Q10. The primary commercial use of idebenone in the United States is as an ingredient in wrinkle creams. Facial creams that contain idebenone are typically used to reduce wrinkles and sun damage.

Presage MD

Presage MD makes two products that contain idebenone. Presage MD Deep Wrinkle Serum contains 5 percent idebenone and is available in a 2-oz. supply. It is intended for deep wrinkles and is activated by body heat. Presage MD Intensive Emulsion contains 3 percent idebenone and is advertised as hypoallergenic. Additional active ingredients of these products include green tea extract, linoleic acid, Vitamin E and an ester of Vitamin C called ascorbyl palmitate.


Priori makes a number of skincare products that contain idebenone. Smooth Lines is an anti-aging moisturizer that contains 0.5 percent idebenone in a 30 milliliter (ml) bottle. It can help to smooth fine wrinkles and protect the skin from aging and environmental factors. Even Tones also contains 0.5 percent idebenone which is intended to treat uneven skin tones.

Professional Solutions

Professional Solutions products are available from skin care professionals such as dermatologists and plastic surgeons. Its wrinkle cream comes in a 1-oz. jar and contains 1 percent idebenone. Professional Solutions claims that its wrinkle cream will visibly improve the appearance of wrinkled or sun-damaged skin within two weeks.


Rejuvaskin’s anti-aging serum is available in a 1-oz. bottle and contains 1 percent idebenone. It also contains polypeptides for the purpose of reducing fine lines and wrinkles. According to the Dermatologist Rx website, clinical studies Rejuvaskin's anti-aging serum showed a 64 percent reduction in fine lines and a 30 percent reduction in wrinkles. Fine wrinkles should become less noticeable within two to three weeks and skin tone should become more even within four to six weeks.