Prior to freezing your calzones, you'll need to wrap them tightly in plastic to prevent freezer burn. Add a layer of aluminum foil to further insulate them and maintain their quality when you defrost them. You can also store your calzones in air-tight freezer bags. When wrapped and frozen at 0 degrees Fahrenheit, you can keep your homemade calzones in your freezer for up to two months. After this time, you can certainly still eat them, but they may not taste their best after reheating. Allow your calzones to cool first before freezing -- and store them within two hours of baking.

Defrost your frozen calzones in the refrigerator for a few hours before heating them in the oven or microwave. You can also microwave them while still frozen, using the "defrost" setting on your microwave, or add five to seven minutes to their cooking time in the oven. Cook all meats to 165 F before using them to fill your calzones to kill any harmful microorganisms before freezing.