Vera Bradley backpacks are durable, made out of 100 percent cotton and come in a variety of styles and colors. The backpacks include pockets for storing small items as well as strong zippers that won't jam or break. But Vera Bradley backpacks do not contain a barrier that repels dust and dirt. The backpacks only require a mild washing, in your home's washing machine or by hand, to keep them clean and free of any odors.

Open your Vera Bradley backpack and remove any contents from the backpack's pockets and other sections.

Remove the solid base in the bottom of the backpack, if the base is not sewn in. You don't have to remove sewn-in bases; they will survive the washing machine.

Set your washing machine on the “Gentle” or “Delicate” cycle. Place your Vera Bradley backpack in the washing machine with the pockets open. Fill the machine with cool water and one capful of mild laundry detergent.

Remove your backpack once the cycle is complete. Place the backpack on a drying rack or hang it on a clothesline for drying.