Sucralose is the only artificial sweetener that can be used to replace sugar cup for cup in a recipe. It is actually made from sugar, so it is just as sweet and has the same volume as real sugar. You can use the granular form of sucralose in any type of recipe because it is heat-stable. However, cookies, cakes, brownies and pies made using sucralose tend to bake faster than those with traditional sugar, so be sure to keep an eye on the oven when baking with it.

If you're baking cookies, cakes or brownies, saccharine is another heat-stable artificial sweetener option. It is 200 to 700 times sweeter than natural sugar, though, and can have an aftertaste if you use a lot of it. As a result, it's best use it by replacing only half of the sugar with saccharine, so you don't add more than a half cup to any recipe when baking. If you are using packets of saccharine, six 1-g packets usually equal 1/4 cup of real sugar.

You can use acesulfame potassium in most of your baking and cooking recipes because it is also heat-stable. Like saccharine, it is actually sweeter than sugar and can have a slight aftertaste if you use too much of it. When baking, combine acesulfame potassium with real sugar and never replace more than 2 cups with the artificial sweetener. When using acesulfame potassium, replace each 1/4 cup of sugar with six 1-g packets of acesulfame potassium.

Of all artificial sweeteners, aspartame is the most heat sensitive. It actually becomes less sweet when exposed to heat, so it should not be used in recipes that require cooking or baking like cookies, cakes or brownies. You can use it in beverages, pie fillings, pudding, gelatin, sauces or other items that you can add it to once you have removed them from the heat. Like saccharine and acesulfame potassium, six packets of aspartame equal 1/4 cup of real sugar.