Supplements to Combat Wrinkles

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Wrinkles, crow's feet, fine lines: If you have them, you will want help. Renowned dermatologists such as Dr. Nicholas Perricone and Dr. Harold Murad agree that what you put in your mouth is reflected on your skin and has an impact on how you combat wrinkles and other signs of aging. There are skin supplements that are thought to make a difference in combating wrinkles. As always, consult your physician before taking them.

Omega-3 Fatty Acids

This supplement is recognized as crucial to a good skincare regimen and combating wrinkles. Eating salmon daily will enable you to glean all the benefits of Omega-3 Fatty Acids, but if you don't care for the taste of fish, take it in supplement form as a fish oil capsule. Usually, 1,000 mg taken two to three times a day with meals will provide anti-wrinkle benefits, thanks to Omega-3's anti-inflammatory properties. Vegetarians can substitute with 1,000 mg of flax seed oil three times a day.

Alpha Lipoic Acid, or ALA

Dr. Perricone has touted the benefits of ALA as a wrinkle fighter since publishing his first best seller, “The Wrinkle Cure,” in 2001. ALA is a powerful antioxidant that is 400 times more potent than vitamins C and E combined. Dr. Perricone recommends 25 to 30 mg daily to decrease inflammation, fight fine lines and wrinkles, and improve skin tone. ALA must be taken in supplement form, as foods contain only small amounts of it.

Coenzyme Q10, or CoQ10

This wrinkle-fighting supplement can be taken on its own or in a multi-vitamin. CoQ10 is an antioxidant and anti-inflammatory that fights free radicals and, in turn, helps to combat wrinkles. Recommended dosage is a minimum of 30 mg a day, and is particularly recommended for individuals over age 40, because natural levels of CoQ10 decrease with age. Women also often have lower natural levels of CoQ10 than men do.

Dimethlaminoethanol, or DMAE

Dr. Perricone is a long-time proponent of DMAE, citing its contributions to skin firmness, smoothness and facial muscle tone. DMAE is present in salmon, but is also available in supplement form. Dr. Perricone recommends 50 to 100 milligrams daily with meals. However, DMAE can cause side effects such as muscle tension or insomnia, and it is contraindicated in people with epilepsy or bipolar depression. Use it only if you are healthy, and exercise caution. Discontinue its use immediately if any side effects occur.

Grape Seed Extract

Grape seed extract is considered a key supplement to combat wrinkles. Dr. Murad recommends it in his “Cellular Water Principal,” noting that this supplement allows cells and tissues to remain hydrated and thus avoid thin, dry, wrinkled skin. Grape seed extract, like Omega-3 fatty acids and CoQ10, helps to fight inflammation and free radicals, and assists with rapid cell turnover, resulting in clearer, smoother, younger-looking skin.

Dehydroepiandrosterone, or DHEA

The jury is still out on DHEA, a hormone that your body creates and that has been synthetically reproduced and marketed as an anti-aging, anti-wrinkle supplement. No research supports these claims. Because no one knows the long-term effects of using DHEA, this supplement is best avoided until further studies are completed. To date, DHEA has been shown to increase androgen and estrogen levels, and is therefore linked to a possible increased risk of cancer.