Advanced Night Repair Protective Recovery Complex by Estee Lauder was first launched in 1990 based on its success Advanced Night Repair Concentrate Recovery Boosting Treatment followed. In May 2009, Estee Lauder introduced Advanced Night Repair Synchronized Recovery Complex replacing the Protective Recovery Complex. The Advanced Night Repair line ingredients expanded with DNA research and led to the discovery that interaction and timing of ingredients is as important as the ingredients.

Found to be a natural agent of moisture in the skin, this ingredient helps skin retain water for a smooth, no flake look. By adding more of this enzyme to the skin care product, the moisture pumps up the skin reducing the appearance of lines and wrinkles.

According to Estee Lauder, this technology supports the natural synchronization of the skin's repair processes and works to repair past damage so it does not become permanent. It is specifically designed to target lines and wrinkles at exactly the right time.

This patented encapsulated repair process attacks damage from pollution, smoke, chemicals and toxins. Akkyl Guanine is a natural enzyme in skin cells that removes alkyl pollutants from the cells DNA. By adding this ingredient to the product the enzyme's natural power is boosted and replenished.

In 2001, University of Utah scientists first discovered the human clock gene. DNA research revealed that proteins are produced in rhythmic patterns. These clock genes help cells maximize the repair of their own DNA but they slow down with age. Understanding this, the Estee Lauder scientists incorporated the clock gene technology into the development of the Advanced Night Repair Synchronized Recovery Complex.

According to on line ratings, nightly use of Estee Lauder Advanced Night Repair Synchronized Recovery Complex produced fast results and reduction of lines was noticeable.

An article published by Business Wire stated that Advanced Night Repair Synchronized Recovery Complex used nightly produced results in three advanced ways and in vitro testing showed that 90 percent of environmentally generated free radicals were neutralized before they could cause damage and affect the appearance of the skin.

Dr. Daniel Maes, senior vice president of Estee Lauder research and development, said "researchers have found that the natural elimination of the alkyl group by the cells was not sufficient to eliminate all the damages caused by the exposure to pollution, hence the need to boost the natural repair mechanism."